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AST (Asterias Biotherapeutics) DD

What is AST?
Asterias Biotherapeutics is a development stage biotechnology company focusing in regenerative medicine. We are developing therapeutics based on two different platform technologies: cancer immunotherapy and pluripotent stem cells. Near term, we are leveraging these platforms to develop treatments to address significant unmet medical needs in oncology and neurology. These mature programs are focused on de-risked indications and are supported by robust proof-of-concept pre-clinical and clinical data.
How/ what are they doing?
Historically, medicine has found few effective therapeutic strategies for biologically complex degenerative diseases. Stem cells offer an unusually powerful new therapeutic platform to treat some of the largest and fastest growing unsolved problems in medicine through the use of healthy and functional human cells to address the underlying mechanisms of complex disease. Asterias’ platform technology is grounded in the intellectual property, materials, and scientific know-how required to develop therapies for degenerative diseases based on pluripotent stem cells.
Stem cells are characterized by their ability to both reproduce themselves and to differentiate into functional tissues, foundational properties that enable their use as the starting material for manufacture of cellular therapeutics to address complex disease. Pluripotent stem cells are the most potent type of stem cells; they have the ability to differentiate into any human cell type and to reproduce indefinitely. This functionality makes pluripotent stem cells an especially powerful candidate for cell therapies, because they can be tailored for specific treatments and manufactured at scale. Pluripotent stem cells should not be confused with “adult” stem cells, which reside naturally in the body but have a finite capacity for reproduction and differentiation.
The first type of human pluripotent stem cells isolated were “human embryonic stem cells” (hES cells). These cells were isolated by Dr. James Thomson at the University of Wisconsin. The first clinical trial of a hES cell-based product was initiated by Geron in 2010. Many of the original researchers involved in that trial have joined Asterias to continue the development of the pluripotent stem cell platform. Our current efforts relating to our pluripotent stem cell platform are focused on developing AST-OPC1 (hES cell-derived neural cells) for the treatment of spinal cord injury and other neurodegenerative diseases, and AST-VAC2 (hES cell-derived immunotherapy) for cancer.
What do their trials look like?
• AST-VAC1 is an autologous (patient-specific) immunotherapy treatment for Acute Myeloid Leukemia (AML) patients. AST-VAC1 has the potential to supplement current chemotherapy regimens in order to improve long-term remission for these patients, as demonstrated in a phase 2 trial.
• AST-VAC2 is an allogeneic (non-patient specific) immunotherapy manufactured from our pluripotent stem cell platform. We have partnered with Cancer Research-UK (CRUK) to investigate AST-VAC2 in non-small cell lung cancer. Additionally, AST-VAC2 has potential applications in a wide range additional cancers, and is likely synergistic with other immunotherapies such as immune checkpoint inhibitors.
• AST-OPC1 are a neural cell type called oligodendrocyte progenitor cells, which we manufacture from our pluripotent stem cell platform. With support of the California Institute for Regenerative Medicine (CIRM) our initial clinical program is developing this cellular therapy for the treatment of spinal cord injury, a devastating condition affecting 12,000 patients per year in the U.S. with no currently approved therapies. We are currently enrolling patients in a Phase 1/2 clinical trial in acute, cervical (neck) spinal cord injury. For more information on clinical trials please see link 4
Other pertinent information:
Asterias acquired the cell technologies and related intellectual property developed through Geron Corporation’s cell therapy programs. These assets included five therapeutic programs with animal proof of concept across therapeutic areas including, neurology, oncology, orthopedics, cardiovascular medicine, and diabetes. Today, Asterias holds over 400 patents and patent applications filed worldwide including broad issued claims to fundamental platform technologies including, but not limited to, the cell immunotherapy using the telomerase antigen, scalable growth of pluripotent stem cells, and compositions of matter for several hESC-derived therapeutic cell types.
Affiliate of BioTime and are traded on the NYSE MKT under the ticker symbol $AST.
Links:
http://www.biospace.com/news_story.aspx?StoryID=443714&full=1
http://www.kurzweilai.net/paralyzed-man-regains-use-of-arms-and-hands-after-experimental-stem-cell-therapy
https://singularityhub.com/2017/01/05/10-tech-trends-that-made-the-world-better-in-2016/?utm_content=buffer7b44b&utm_medium=social&utm_source=facebook-hub&utm_campaign=buffer
http://asteriasbiotherapeutics.com/pipeline/ast-opc1/
http://www.ipscell.com/?s=Asterias&submit=Search
Notes:
I am long 200 shares and thinking that there will be good news on Tuesday 01/24/17, and am bullish
My strategy for this stock is long-term hold, selling half my position after news causes the price to spike and buying more when the price settles back down days or weeks later
Have done this DD mostly by reading the company website (a fuckton of copypasta)
I have also googled and looked into links provided by others in the $AST 6-month efficacy data coming on the 24th post
I like the idea of using stem cells for regenerative therapy
Have only looked into this company this weekend because of the previous post mentioning it
edit: formatting
submitted by vinoyolo to wallstreetdd

Do Not Join Unkown CS Source Servers Via IP Address - CAN DOWNLOAD HIJACKING RAT AND GET YOU VAC'd

*** Unbanned and skins restored on 9/29/2015!!! See Details ***
(Thank you for all the upvotes AND the posts on http://steamcommunity.com/profiles/76561198116049549 ... You guys rule.)
SUMMARY
  • I was hijacked via malware from a CS Source server and before securing my account was VAC Banned, lost all my inventory, and ESEA banned all in a two hour period.
  • WHAT I COULD HAVE DONE TO PREVENT *
https://www.reddit.com/GlobalOffensive/comments/3kl5q6/avoid_having_csgo_items_stolen_account_hijacked/
CEVO RESPONSES
Unbanned by Spangler on 9/7/2015
VALVE RESPONSES
  • REPLY FROM VALVE SECURITY!!!! 9/5/2015 - 12:14AM PST
"[email protected] 11:41 AM (32 minutes ago) to me, Security
Thanks for the report, we are working on a fix for this."
"[email protected] 9/7/2015 - 9:10 AM 9:10 AM to me, Security Our support team will deal with your ban separately.
  • NO RESPONSE ON MY SKINS OR VAC STATUS =(
ORIGINAL POST
Dear people of the community,
I have played since 99 in and out of leagues on all flavors of CS (execpt CZ of course) and have never clicked on links and am fully aware of phising and hijacking attempts.
I am sure it has happened before but if it tricked me it could trick someone else so, be careful.
I connected to help a contact on my list (who previously accoused me of cheating on ESEA so I probably should have ignored him) with a CS:Source video.
The server crashed my game and we decided to give up. I noticed my game minimizing and by that point went into safe mode to remove the infection. When I got back into windows with a clean PC it was too late.
My skins were traded to another person and then showed up in the person who I was helpings account. Karambit Doppler and countless other nice skins, 6 of them with Titan (Holo) | Katowice 2014 stickers.
I was also VAC banned and ESEA banned from DM hacking and an ESEA hack pug which was streamed by bloominator. They posted a screenshot of "me" with with the cheats on in a deathmatch (with the score 0-5 lol) and messaged all my friends that I had got vac'd.
Check out my steam account, check steamcommunity.com/id/LividS and my esea account Livid.
Apparently from inside my PC they were able to steal the steamguard files and put them on their own PC so steamguard was completely circumvented.
This is going to be a problem getting my skins back I imagine because of the blatant hacking on my account. This all happened in a two hour period.
The ESEA demo shows them clearly admiting to stealing my account and how they did it. They messaged all my contacts about it and my friend initiated a conversation where they invited him to mumble. I came in the mumble and they explained how they felt bad and offered some of my skins back if I would help them get other victims. I obviously declined. They denied it was through the CS Source server however, the processes running were comming from the Source directory and then put files in my documents and a few folders in AppData.
They had control of my microphone and referenced my prior team practice mumble conversations.
This is pretty messed up only because I thought I was helping someone out and had no idea that connecting to a gaming server could be so insecure.
I explained this in a steam ticket. Any suggestions?
NOTE
This is the user http://steamcommunity.com/profiles/76561198116049549 (hackergod) who tricked me into helping him and is blatantly displaying my m4a4 assi and p250 mehndi with Titan Holo stickers... Note his CS Source gaming yesterday for .3 hours...
NOTE
It was pointed out to me that I do not have CS:Source... I do not on the account that got hacked which is why when asked I added the guy on my other account, /id/SweaseL, which was my pain account with over 3,000 hours. I switched to using my 5 digit because the legit-proof was not tied to my personal information but I guess that dream is dead anyway.
You can follow CEVO history to see that SweaseL and I are the same person and ask about anyone else that knows me.
  • Note that SweaseL played Source yesterday. Steam devs should be able to confirm this via chat records, assuming they are stored, between me and hackergod from my LividS account to my Sweasel account where I said I would need to switch accounts to access Source.
IMAGE OF STOLEN ITEMS
http://imgur.com/jCJ4bnW
LINK TO BLOOMINATOR'S STREAM W/HACKERS IN PUG ON ESEA
http://www.twitch.tv/bloominatov/14349473 (note they admit to hacking my account and trying to get it banned)
ACTUAL ESEA DEMO LINK
https://play.esea.net/index.php?s=stats&d=match&id=5305736
THEIR MUMBLE IF ANYONE IS INTERESTED
-removed to protect mumble owner-
SCREENSHOT A FRIEND SENT OF MESSAGE FROM HACKER
https://gyazo.com/afacf0bc54e2c9bca780861b16242594
A 3RD USER CLAIMS TO HAVE BEEN HACKED THE SAME WAY, HERE IS THE IP OF THE SERVER HE CONNECTED TO: 162.253..66.218 (I can not confirm or deny that this is the same IP as I was not paying close attention).
LATEST DEVELOPMENTS
  • 9/5/2015 9:51 AM PST - So hackergod finally returned back online and is posting in his comments things like "Who did I hack?" etc. etc.
He messaged and in the process, I noticed that I have my message to him yesterday to add me on my other account (where I have source) to help him... It is funny to say the least. On the same screenshot I also show where the account that my skins were traded to (I Steal Skins) or... http://steamcommunity.com/profiles/76561198229071220 just added me as well! I accepted to see if maybe he was going to magically give me all my skins back but instead he was offline so I unfriended him. I suspect he was adding me to backup what ol' hackergod was saying which is complete nonsense (that I indeed hacked him).
Screen shots here (forgive me part 2 and 3 got pasted wrong and the history is gone):
Part 1: http://i.imgur.com/cTNX7TP.jpg Part 2: http://i.imgur.com/EP4pPG7.jpg Part 3: http://i.imgur.com/9K9E9YH.jpg Part 4: http://i.imgur.com/ZgSRBua.png
In the end he basically says that he did have the doppler and traded for the tiger bayo and that he never had an assimov or p250 with the titan sticker and that he just got hacked and lost all his skins. He said that "hotboy tj" gave him the skins in the first place but now they are gone because he got hacked. hotboy tj is where my skins were traded to and where other users are reporting their skins being traded to as well.
Also, since I have shown you where I tell hackergod I will get on my other account, from my other account I also have him saying if he gets the server to work he will let me know. This is after the source server did not work: http://i.imgur.com/UjivtJY.jpg
Ultimate Summary That I Sent To Steam
So what happened here:
  • I connect to Valve software via Steam & malware is downloaded to my PC
  • Instantly hackers are able to steal my steam password & blob files for steamguard + other passwords via Chrome keychain (like my ESEA password)
  • Hackers then log into steam via their own PC, disable trade verification, trade away my skins, then go wild...
I know steamguard was bypassed because my email login history shows no additional users and my PC was not taken over for long. I was on the computer the whole time and my mouse was not taken over etc etc.
I think trade verification should not be able to be turned off without email confirmation. They would not have been able to get into my email and that would have prevented this entire thing... and if steamguard actually worked.
submitted by bsadams to GlobalOffensive

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